Teratogen Update: Environmentally Induced Birth Defect Risks
نویسندگان
چکیده
منابع مشابه
Teratogen Update: Environmentally Induced Birth Defect Risks
Our society's expectations of perfect babies, coupled with a belief that someone should be held responsible for birth defects, makes legal action on behalf of congenitally malformed infants common. In some instances the alleged cause of the malformation is exposure to drugs, industrial chemicals, radiation, or infectious agents. A convenient source of pertinent information on the etiology, path...
متن کاملTeratogen update: paternal exposures-reproductive risks.
The potential of many drugs and chemicals to cause prenatal harm is well-established. The types of effects seen vary and include spontaneous abortions, stillbirths, congenital malformations present at birth, and conditions detected only months to years after birth. Most studies designed to determine whether agents cause malformations have examined the effects of exposure of the embryo or fetus ...
متن کاملTeratogen update: iodine deficiency, a community teratogen.
In the last decade, iodine deficiency disorders (IDD) have become recognized as the most common preventable cause of mental retardation worldwide. Iodine deficiency interferes severely with prenatal and postnatal growth and neurologic development of individuals. It has condemned tens of millions of children to cretinism—characterized by mental and growth retardation, rigid spastic motor disorde...
متن کاملTeratogen update: inorganic arsenic.
BACKGROUND Inorganic arsenic has been used by many laboratories to study the pathogenesis of exencephaly in rodents. These studies, which used predominantly injection exposures, coupled with the paucity of epidemiology data, resulted in the erroneous inference that inorganic arsenic should be considered a human teratogen. METHODS This study assembles and assesses literature analyses of older ...
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Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been used for the treatment of malignancy, rheumatic disorders, and psoriasis and termination of intrauterine pregnancy. Recently, methotrexate has become a standard treatment for ectopic pregnancy. The...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1988
ISSN: 1468-6244
DOI: 10.1136/jmg.25.1.66